There is no reason to assume?
So when we buy an unfamiliar gadget, there is no reason to assume we must use that gadget according to the instructions manual that comes with it.
We can use it anyway we want, and for whatever purpose we want.
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In reality, that's what many have chosen
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Every day, 29 people in the United States die in motor vehicle crashes that involve an alcohol-impaired driver.1 This is one death every 50 minutes.1 The annual cost of alcohol-related crashes totals more than $44 billion.
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Problem Drinking and Promiscuity
Scientists have long believed that the environment has a role to play in triggering risky sexual behavior and problem drinking tendencies. But they now know that certain unique structural features of the brain can predict if an individual will abuse alcohol or show promiscuous behavior in reaction to stress.
Addictive tendencies triggered by stress
Early-life stresses, such as being raised in an abusive household, can alter brain chemistry and functionality and may trigger substance use and abuse tendencies.
Problems with Promiscuity
I don't want to fill up a page with all the problems man has created, and are unable to solve, because of seeking their own purpose, and doing things their way - Using their lives in various ways.
However, as you rightly said, it's up to us - our choice. We get to choose how to destroy our lives,
Or try to preserve it by our own means... regardless of how futile it proves to be.
Not meaning to sound negative, but facing reality or denying it, and hoping otherwise, is also a choice.
Just as we know - we don't need a degree in rocket science to know - we know that an instruction manual is provided by the manufacture, for the purpose of guiding the user, in the proper way for using his "not so simple" design, and taking care of it, common sense tells us that the designer of life would know the proper guidelines for his design to work to its fullest and best, and last longer - even forever, if it was designed to last that long.
So that's why some choose to consult the manual to hear from the manufacturer of life, because they know that using the "tools" the proper way, usually results in it lasting longer, and not being unnecessarily damaged.
If God is, and the evidence indicates that to be the case, then he has a purpose - one purpose, for his creation.
Of course that does not mean there is no variety, as is present in the variety of plants, animals, foods, etc.
It just means that one purpose is his overall purpose.
Thus there is good reason to assume that living our lives in harmony with, or in accord with his will, since he will fulfill his purpose - which the Bible says involves everlasting life.
Although for us, it's not an assumption.