This reference concerns the mechanism of the chemical evolution of inorganic phosphates to organic phosphates.
From:
Scientists Just Found a Vital Missing Link in The Origins of Life on Earth
Scientists Just Found a Vital Missing Link in The Origins of Life on Earth
Meet diamidophosphate.
MIKE MCRAE
7 NOV 2017
Carbon might be the backbone of organic chemistry, but life on Earth wouldn't be what it is today if it weren't for another critical member of the periodic table – phosphorus.
Transforming run of the mill hydrocarbons into the kinds of molecules that include this important element is a giant evolutionary leap, chemically speaking. But now scientists think they know how such a vital step was accomplished.
Researchers from The Scripps Research Institute in California have identified a molecule capable of performing phosphorylation in water, making it a solid candidate for what has until now been a missing link in the chain from lifeless soup to evolving cells.
In the
classic chicken and egg conundrum of biology's origins, debate continues to rage over which process kicked off others in order to get to life. Was RNA was followed by protein structures? Did metabolism spark the whole shebang? And what about
the lipids?
No matter what school of
abiogenesis you hail from, the production of these various classes of organic molecules requires a process called phosphorylation – getting a group of three oxygens and a phosphorus to attach to other molecules.
Nobody has provided strong evidence in support of any particular agent that might have been responsible for making this happen to prebiotic compounds. Until now.
"We suggest a phosphorylation chemistry that could have given rise, all in the same place, to oligonucleotides, oligopeptides, and the cell-like structures to enclose them,"
says researcher Ramanarayanan Krishnamurthy.
Enter
diamidophosphate (DAP).
Combined with imidazole acting as a catalyst, DAP could have bridged the critical gap from early compounds such as
uridine and
cytidine. That might not seem overly exciting, but phosphorylating
nucleosides like these is a crucial step on the road to building the chains of RNA that could serve as the first primitive genes.