In 2008 Albert Hofmann, who first synthesised LSD, died. He had been lobbying the US government for many decades to establish a center for research into psychedelic compounds. This will probably never happen in our lifetime, which is a great shame. Ann Shulgin is the wife of Alexander Shulgin, a famous chemist responsible for synthesising hundreds of new psychedelic compounds. She works, illegally, in the field of MDMA-assisted therapy. Her results with treatment of various conditions, most notably PTSD, have been very impressive. This was mentioned in an article in Scientific American, which noted that cases had been completely resolved in a matter of hours. This is as much a testimony to her sensitivity and skill as it is to the potential of such compounds. This is the crucial point. My observation of the recreational use of MDMA (ecstacy) leads me to believe that it is generally not worth the risk people take with their physical and mental health, because the experience is handled in such a shallow, even stupid, way. Most users of these substances really just want their dance club experience enhanced, and any mind expanding or insight inducing effects are incidental and very short-lived.
Without a shamanic tradition to guide people, the experience is unpredictable, chaotic and often detrimental. So my advice in general is don't indulge in mind-altering substances.
So on reflection I wish I had not posted my remarks in this thread, because I realise that it could encourage very unwise experimentation from people who have no guidance, or knowledge, or background in meditative practice. For that reason, I would even say that I would feel more comfortable if this thread was removed, because it could well be seen as an endorsement and encouragement by young, inexperienced and unsupported individuals who may suffer as a consequence. The psychedelic experience is not trivial, and its effects, for better or worse, can last a lifetime.