I think both of the posters who have responded to my OP misunderstood what I way getting it. Let's take Judas, for instance -- since he is often mentioned as being unfairly maligned for his betrayal of Christ. I've heard people question whether or not he can really be held responsible for turning against Jesus since it appears to have been God's plan that His Son be crucified to redeem us, and Judas was, after all, just fulfilling God's plan.
Okay, to take this one step further... If God knows everything that's going to happen to every single person from the moment that person is born until he dies, then can the individual who pulls a gun in a crowded McDonald's, kills three innocent people and injures another dozen really be held responsible for what he did? If he hadn't done it, the people who died would not have died at the time God had predetermined they should die. The injured people's lives would not have been affected as God knew they would be if the gunman had had second thoughts. So was the gunman really doing anything other than fulfill the purpose God intended him to fulfill when He placed him here on earth?