I don't disagree with anyone that social interaction is healthy, and that its hard to weather not having it. Like Saint Frankenstein has said, you do crack up... but most of us that have to 'crack up' live through it. Some don't. But there are other things some of us don't live through(I'm referring to suicide), like the death of a loved one, loss of job or fortune, or feeling alienated within a culture. If someone feels like they're getting that low, some kind of intervention is required(what that is will vary). But most people who will have to stay home for Thanksgiving this year are going to be upset/depressed, but not necessarily suicidal.
I went through that 'crack up' a few years ago. I'm a pretty social person; a quiet extrovert is what I like to call myself. In my younger years, the most horrible thing I could imagine was no one to call, no one to visit, etc. And then it happened. Friends moved. Others grew apart. Long story short, all those people I 'needed' disappeared. And I was alone, other than my family I live with. The same thing happened with my husband as well(he failed to make friends in Midwestern culture).
I was stinking miserable. I cried a lot about it. Of course, I tried to make new friends, but it never worked. I put myself out there, joined up, but no matter what I did, a casual conversation was all I would find. And that wasn't totally uplifting("so, is it still raining outside?" kinda thing).
The thing was, I found, no one cared. They really don't, unless its in some abstract way; no one gave a **** that I was lonely and suffering. And once I took that to heart, strangely, I started to heal. No, there really wasn't anyone who cared, or that was going to fix my problem, or help me fix it, so I better get used to it. If I didn't want to go nuts, I had better accept things the way they are, and be thankful for what I have.
I have been living Covid style since before Covid was a thing. Do I think everyone should do it? Absolutely not. Do I want to continue to be isolated? Absolutely not. Will I fall apart if I have to? Absolutely not.
I think if you have friends to go spend time with after this stinking virus lifts, its something to be thankful for. Personally, I am thankful for the fact I'm not living alone. My heart goes out to those that have to live alone during this(unless, of course, they're very introverted and prefer it that way).