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The revenge of hydroxychloroquine

Discussion in 'Current Events' started by Shaul, Nov 26, 2020.

  1. suncowiam

    suncowiam Well-Known Member

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    Also, the only proponents of hydroxychloroquine should be scientists that understands hydroxychloroquine, malaria, and covid related issues to even possibly suggest continuing research.

    If, we have regular citizens with no medical background being proponents then I will argue that their basis is completely false.
     
  2. suncowiam

    suncowiam Well-Known Member

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    I never suggested to ignore hydroxychloroquine. I only suggest to be neutral until more data suggests otherwise.

    But most that argue for hydroxychloroquine without a medical background are repeating political talking points.
     
  3. Shadow Wolf

    Shadow Wolf Rival's Wife

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    It's proposed use is for malaria.
    Come back when the studies show hydroxychloroquine actually works, because we have a legion of studies that say it doesn't.
     
  4. Jayhawker Soule

    Jayhawker Soule <yawn> ignore </yawn>
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    Folks should actually read the report and make an honest attempt to understand what it says and what can be reasonably inferred from it.
     
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  5. Jaiket

    Jaiket Well-Known Member
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    Any news on whether we should start injecting bleach?
     
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  6. metis

    metis aged ecumenical anthropologist

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    There are more effective remedies that are at least somewhat safer, such as steroids, which has proven to be quite effective. On top of that, what you posted in your OP isn't effective by itself according to some studies.

    Thus, maybe it's best to get off the sarcasm and maybe actually spend some time on researching multiple sources.
     
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  7. ChristineM

    ChristineM "Be strong" I whispered to my coffee.
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  8. Jayhawker Soule

    Jayhawker Soule <yawn> ignore </yawn>
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    From the study ...

    ABSTRACT
    The aim of this study was to describe the outcomes of patients with coronavirus disease 2019 (COVID-19) in the outpatient setting after early treatment with zinc, low-dose hydroxychloroquine and azithromycin (triple therapy) dependent on risk stratification. This was a retrospective case series study in the general practice setting. A total of 141 COVID-19 patients with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the year 2020 were included. The main outcome measures were risk-stratified treatment decision and rates of hospitalisation and all-cause death. A median of 4 days [interquartile range (IQR) 3–6 days; available for n = 66/141 patients] after the onset of symptoms, 141 patients (median age 58 years, IQR 40–67 years; 73.0% male) received a prescription for triple therapy for 5 days. Independent public reference data from 377 confirmed COVID-19 patients in the same community were used as untreated controls. Of 141 treated patients, 4 (2.8%) were hospitalised, which was significantly fewer (P < 0.001) compared with 58 (15.4%) of 377 untreated patients [odds ratio (OR) = 0.16, 95% confidence interval (CI) 0.06–0.5]. One patient (0.7%) in the treatment group died versus 13 patients (3.4%) in the untreated group (OR = 0.2, 95% CI 0.03–1.5; P = 0.12). No cardiac side effects were observed. Risk stratification-based treatment of COVID-19 outpatients as early as possible after symptom onset using triple therapy, including the combination of zinc with low-dose hydroxychloroquine, was associated with significantly fewer hospitalisations. ...

    4.1. Potential implications for clinicians and policy-makers
    Clinical experience from severely ill inpatients with pneumonia who were treated with high-dose HCQ is not readily transferable to the outpatient setting with upper respiratory tract disease only. For outpatients with a median of only 4 days after onset of symptoms, COVID-19 represents a totally different disease and needs to be managed and treated differently [63]. A simple-to-perform outpatient risk stratification, as shown here, allows for rapid treatment decisions and treatment with the triple therapy of zinc, low-dose HCQ and azithromycin and may prevent a large number of hospitalisations and probably deaths during the SARS-CoV-2 pandemic. This might also help to avoid overwhelming of healthcare systems.

    [emphasis added = JS]​

    If I'm reading this correctly, the study provides evidence for the efficacy of low-dose hydroxychloroquine treatment in of "outpatients with a median of only 4 days after onset of symptoms" in which "COVID-19 represents a totally different disease and needs to be managed and treated differently." If true. this is very good news in the abstract. It is also very strong evidence for the critical importance of widespread, early, and persistent testing and rapid intervention, both of which were maximally crippled by the Trump Administration whose response was one of compulsive dishonesty and malignant neglect - all made possible by the complicit.
     
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  9. metis

    metis aged ecumenical anthropologist

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    You're being very nasty, JS, as Trump and his staunch supporters don't want science-- just rancid partisan politics. Shame on you! :mad:
     
  10. Shaul

    Shaul Well-Known Member

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    It isn’t proposed for treating malaria, it is established for use treating malaria. The study I cited shows it also works as a treatment for Covid-19.
     
  11. Shadow Wolf

    Shadow Wolf Rival's Wife

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    No, you gave a study that mentioned multiple things and it did not once say specifically that hydroxychloroquine works. And, again, we have a mountain range of studies that show it doesn't.
     
  12. Shaul

    Shaul Well-Known Member

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    The proponents of using hydroxychloroquine as a therapy for Covid-19 have consistently stated it was for use in the early stages. The Trump administration is most responsible for the rapid increase in testing availability. The opposite of crippling it.
     
  13. Shaul

    Shaul Well-Known Member

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    Quoting from the highlights of the study it reads, “


    First COVID-19 outpatient study based on risk stratification and early antiviral treatment at the beginning of the disease.


    Low-dose hydroxychloroquine combined with zinc and azithromycin was an effective therapeutic approach against COVID-19.
     
  14. Jayhawker Soule

    Jayhawker Soule <yawn> ignore </yawn>
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    Absolute lie.
     
  15. metis

    metis aged ecumenical anthropologist

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    Indeed, as the Trump administration pushed the vast majority of the testing off to the individual states, who then had to compete against each other for materials while themselves being strapped for funds.
     
  16. Shadow Wolf

    Shadow Wolf Rival's Wife

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    That means it's not a miracle redemption for hydroxychloroquin and makes it inaccurate to say hydroxychloroquin works.
    We still have a mountain of studies that say it doesn't work. This study says that in a low dose combined with other things appears to work. But one study doesn't change or negate the many others saying it doesn't work.
     
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