Everything changes our brain; it is like when we are born we have vast amounts of brain cells, that we end up not using so they die off...But it need not be the drug impact it can be the "drive to experiment yourself" that changes the brain.
Like these could possibly be things like telepathy, empathy, dynamic interaction, etc, and because the child never got an opportunity to use them, they were never switched on.
Now as you've experienced Ayahuasca, you maybe aware of how it brings everything back into consciousness, to fix the bits that are cluttering up the subconscious.
After any psychedelic experience the brain makes that many new pathways, that it can never be the same.
As certain strains of cannabis are being recognized to promote creativity, trance, imaginative, meditative, calm, etc; this is most likely as they're specifically affecting that specific cannabinoid receptor in the brain, that operates them states.
So imagine if we've got a person who hasn't ever used their creative brain properly, the addition of these specific cannabinoids in their diet could help them over come their inner lack.
Can we drive our self through will, to create new pathways that didn't exist?
Sometimes; yet often how can we create an interest in something, if we can't even know it is possible.
Thus we have many religious people claiming states, that are really only attainable with the correct herbs that were taken, to comprehend what was written properly.
In my opinion.