Random mutations occur all the time, most have no apparent effect. But the mutations don't accumulate randomly. The useful ones are retained and the harmful ones weeded out, that's why it's called natural selection.
I'm not an expert by in the study of DNA or evolutionary processes or even biology as a general field.
Here's link that talks about mutations.
They talk abut neutral mutations, beneficial mutations, and harmful mutations.
In particular, it says that, "Many other mutations have no effect on the organism because they are repaired before
protein synthesis occurs.
Cells have multiple repair mechanisms to fix mutations in
DNA."
So
mutations in effect aren't really random because not all the mutations that could occur are permitted. That is a very good thing because random mutations would end up being destroying our bodies. The mutations that are allowed are those that fit into the design and the criteria of the design is not "survival of the fittest".
Natural Selection is the process by which organisms better adapted to their environment
tend to survive and produce more offspring. I agree that natural selection does occur, but how exactly is it occurring in people today? Are people dying before they pass on their DNA? I don't think so. But if it's true that people are not actually prevented from passing their DNA because of death, then how is the selection process actually taking place?
It's not happening the way that I was taught in school. Let's look at the example of the bright green beetles and the brown beetles. The birds come along and eat the bright green beetles and not the brown ones, so that results in more brown beetles and fewer green beetles. "Survival of the fittest" meant green beetles weren't reproducing. This is essentially how I was taught natural selection took place. The reality is that I was taught a model for evolution that was like trying to use a bulldozer to play Jenga!
But it turns out that completely different mechanisms are actually involved in the process. Scientists still call it natural selection, but it isn't the same natural selection that I learned in school. We have "negative selection" and "cell repair" and a whole lot of other things going on that show
evolution isn't quite so random.
But let's take a step back. The OP states:
Orthogenesis also known as orthogenetic evolution is an obsolete biological hypothesis that organisms have an innate tendency to evolve in a unilinear fashion due to some internal mechanism or "driving force".-wikipedia
Makes sense to me. As opposed to the theory that we are a random accident.
I agree: orthogenetic evolution is an obsolete biological hypothesis.
But does it make sense to me (as opposed to the theory that we are a random accident)? Yes.
Why?
1. I always found it difficult to believe that organisms around me are changing randomly.
In fact, random mutations would devolve us.
2. It turns out that there are mechanisms that prevent random changes to our DNA.
And I am unconvinced that scientists fully understand these changes.
3. Any system that is sufficiently complex appears random.
i.e. the weather, pseudo-random number generators, card shuffling, die rolling, etc.
Conclusion: I can't accept orthogenesis without informative articles to support it but I am also not confident that scientists fully understand anything in the physical world that they have decided is "random". Doesn't "random" really just mean that they don't know (can't predict) it?